The role of newly born magnetars in gamma-ray burst X-ray afterglow emission: Energy injection and internal emission

Swift observations suggest that the central compact objects of some gamma-ray bursts (GRBs) could be newly born millisecond magnetars. Therefore, considering the spin evolution of the magnetars against r-mode instability, we investigate the role of magnetars in GRB X-ray afterglow emission. Besides modifying the conventional energy injection model, we pay particular attention to the internal X-ray afterglow emission, whose luminosity is assumed to track the magnetic dipole luminosity of the magnetars with a certain fraction. Following a comparison between the model and some selected observational samples, we suggest that some so-called canonical X-ray afterglows including the shallow decay, normal decay, and steeper-than-normal decay phases could be internally produced by the magnetars (possibly through some internal dissipations of the magnetar winds), while the (energized) external shocks are associated with another type of X-ray afterglows. If this is true, then from those internal X-ray afterglows we can further determine the magnetic field strengths and the initial spin periods of the corresponding magnetars. © 2010. The American Astronomical Society. All rights reserved.published_or_final_versio

High-redshift gamma-ray bursts: Observational signatures of superconducting cosmic strings?

The high-redshift gamma-ray bursts (GRBs), GRBs 080913 and 090423, challenge the conventional GRB progenitor models by their short durations, typical for short GRBs, and their high energy releases, typical for long GRBs. Meanwhile, the GRB rate inferred from high-redshift GRBs also remarkably exceeds the prediction of the collapsar model, with an ordinary star formation history. We show that all these contradictions could be eliminated naturally, if we ascribe some high-redshift GRBs to electromagnetic bursts of superconducting cosmic strings. High-redshift GRBs could become a reasonable way to test the superconducting cosmic string model because the event rate of cosmic string bursts increases rapidly with increasing redshifts, whereas the collapsar rate decreases. © 2010 The American Physical Society.published_or_final_versio

The luminosity function of Swift long gamma-ray bursts

The accumulation of Swift observed gamma-ray bursts (GRBs) has gradually made it possible to directly derive a GRB luminosity function (LF) from the observational luminosity distribution. However, two complexities are involved: (i) the evolving connection between GRB rate and cosmic star formation rate; and (ii) observational selection effects due to telescope thresholds and redshift measurements. With a phenomenological investigation of these two complexities, we constrain and discriminate two popular competing LF models (i.e. the broken-power-law LF and the single-power-law LF with an exponential cut-off at low luminosities). As a result, we find that the broken-power-law LF may be more favoured by observations, with a break luminosity L b= 2.5 × 10 52ergs -1 and prior- and post-break indices ν 1= 1.72 and ν 2= 1.98. Regarding an extra evolution effect expressed by a factor (1 +z) δ, if the metallicity of GRB progenitors is lower than ~0.1Z ⊙ as expected by some collapsar models, then there may be no extra evolution effect other than the metallicity evolution (i.e. δ approaches zero). Alternatively, if we remove the theoretical metallicity requirement, then a relationship between the degenerate parameters δ and Z max can be found, very roughly, δ~ 2.4(Z max/Z ⊙- 0.06). This indicates that extra evolution could become necessary for relatively high metallicities. © 2011 The Authors Monthly Notices of the Royal Astronomical Society © 2011 RAS.published_or_final_versio

Implications Of Fast Radio Bursts For Superconducting Cosmic Strings

postprin

Magnetic ordering at the edges of graphitic fragments: Magnetic tail interactions between the edge-localized states

To understand the formation mechanism of magnetic moments at the edges of graphitic fragments, we carry out first-principles density-functional calculations for the electronic and magnetic structures of graphitic fragments with various spin and geometric configurations. We find that interedge and interlayer interactions between the localized moments can be explained in terms of interactions between the magnetic tails of the edge-localized states. In addition, the dihydrogenated edge states as well as Fe ad-atoms at the edge are studied in regard to the magnetic order and proximity effects.open28621

Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla

<p>Abstract</p> <p>Background</p> <p>Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) because it is the origin of a life-and-death signal that sequentially increases (pro-life) and decreases (pro-death) to reflect the advancing central cardiovascular regulatory dysfunction during the progression towards brain stem death in critically ill patients. The present study evaluated the hypothesis that heme oxygnase-1 (HO-1) may play a pro-life role as an interposing signal between hypoxia-inducible factor-1 (HIF-1) and nitric oxide synthase I (NOS I)/protein kinase G (PKG) cascade in RVLM, which sustains central cardiovascular regulatory functions during brain stem death.</p> <p>Methods</p> <p>We performed cardiovascular, pharmacological, biochemical and confocal microscopy experiments in conjunction with an experimental model of brain stem death that employed microinjection of the organophosphate insecticide mevinphos (Mev; 10 nmol) bilaterally into RVLM of adult male Sprague-Dawley rats.</p> <p>Results</p> <p>Western blot analysis coupled with laser scanning confocal microscopy revealed that augmented HO-1 expression that was confined to the cytoplasm of RVLM neurons occurred preferentially during the pro-life phase of experimental brain stem death and was antagonized by immunoneutralization of HIF-1α or HIF-1β in RVLM. On the other hand, the cytoplasmic presence of HO-2 in RVLM neurons manifested insignificant changes during both phases. Furthermore, immunoneutralization of HO-1 or knockdown of <it>ho-1 </it>gene in RVLM blunted the augmented life-and-death signals exhibited during the pro-life phase. Those pretreatments also blocked the upregulated pro-life NOS I/PKG signaling without affecting the pro-death NOS II/peroxynitrite cascade in RVLM.</p> <p>Conclusions</p> <p>We conclude that transcriptional upregulation of HO-1 on activation by HIF-1 in RVLM plays a preferential pro-life role by sustaining central cardiovascular regulatory functions during brain stem death via upregulation of NOS I/PKG signaling pathway. Our results further showed that the pro-dead NOS II/peroxynitrite cascade in RVLM is not included in this repertoire of cellular events.</p

Factors influencing audio-visual comfort evaluation in the metro commercial space

Metro commercial spaces have a potential audio-visual problem because of lack of outside openings. China has built plenty metro commercial entities with its rapid urban development, in which the audio-visual comfort has been concerned as current situation is not good. In order to improve space quality and then enhance staying willing in the metro commercial space, this paper illustrates a study of influencing factors on aural and visual comfort in the metro commercial space. The study takes three metropolises (Shenzhen, Hong Kong and Guangzhou) into account and investigated 103 metro commercial cases. In the study, the spatial differences on aural and visual comfort were firstly examined, and then physical factors of the acoustic and visual environments were considered. It is found that correlations of various acoustic and visual environmental factors on aural and visual comfort were not significant as the correlation value is rather low. If taking spatial differences into account, closer relations could be found. It discovered that visual environmental factors could influence aural comfort, and the vice versa. The factors of saturation, brightness, illuminance and roughness from the visual environment, and sound level and sources from the acoustic environment, are significantly influence aural and visual comfort especially to a typical spatial type of the metro commercial space

Modeling of the current density distribution under surface posterior-tibial-nerve electric stimulator

Stimulation of the posterior tibial nerve is commonly used in the measurement of somatosensory evoked potential (SEP). To improve the efficiency of stimulation, the potential field and current density distributions under the surface electrodes were modeled and simulated. In our model, three layers were assumed: (1) the air environment, (2) electrode and paste (3) human body (skin and soft tissues). The mirror method was used to analyze the potential field of point charge. Integration of the field and the area of the stimulus gave the potential field of one surface electric pole. The potential field distribution of the bipolar stimulator was obtained by superimposition of two unipolar fields. Finally, the current density distribution was calculated by Laplace equation. The analytical solution of the potential field was found and the numerical solution of the current density distribution calculated. The potential field and current density distributions were simulated by 2-D plot. From the model and simulation, the potential and current density distributions were not found to be uniform under transcutaneous stimulation electrode and the maximum current density is located under the poles. We recommend that bipolar stimulator should be applied axially along the stimulated nerve course.published_or_final_versio

Content-aware photo collage using circle packing

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Development of human single-chain antibodies against SARS-associated coronavirus.

The outbreak of severe acute respiratory syndrome (SARS), caused by a distinct coronavirus, in 2003 greatly threatened public health in China, Southeast Asia as well as North America. Over 1,000 patients died of the SARS virus, representing 10% of infected people. Like other coronaviruses, the SARS virus also utilizes a surface glycoprotein, namely the spike protein, to infect host cells. The spike protein of SARS virus consists of 1,255 amino acid residues and can be divided into two sub-domains, S1 and S2. The S1 domain mediates the binding of the virus to its receptor angiotensin-converting enzyme 2, which is abundantly distributed on the surface of human lung cells. The S2 domain mediates membrane fusion between the virus and the host cell. Hence two strategies can be used to block the infection of the SARS virus, either by interfering with the binding of the S1 domain to the receptor or by blocking the fusion of the virus with the cell membrane mediated by the S2 domain. Several antibodies against the S1 domain have been generated and all of them are able to neutralize the virus in vitro and in vivo using animal models. Unfortunately, point mutations have been identified in the S1 domain, so that the virus isolated in the future may not be recognized by these antibodies. As no mutation has been found in the S2 domain indicating that this region is more conserved than the S1 domain, it may be a better target for antibody binding. After predicting the immunogenicity of the epitopes of the S2 domain, we chemically synthesized two peptides and also expressed one of them using a recombinant DNA method. We screened a phage displaying library of human single-chain antibodies (ScFv) against the predicted epitopes and obtained a human ScFv which can recognize the SARS virus in vitro